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Both semaglutide and liraglutide are MHRA-approved and are supported by NICE technology appraisals TA875 for semaglutide and TA664 for liraglutide which set out specific eligibility criteria

Monocytes and macrophages promote endothelial proliferation and tight junction reassembly during specific circadian phases (102), while astrocyte-derived rhythmic inflammatory factors, such as basic fibroblast growth factor, can worsen BBB dysfunction through peripheralcentral signaling (103)